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Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes.

Identifieur interne : 001033 ( Main/Exploration ); précédent : 001032; suivant : 001034

Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes.

Auteurs : Shiqin Peng [République populaire de Chine] ; Ping Wei [République populaire de Chine] ; Qun Lu [République populaire de Chine] ; Rui Liu [République populaire de Chine] ; Yue Ding [République populaire de Chine] ; Jiuliang Zhang [République populaire de Chine]

Source :

RBID : pubmed:30320140

Descripteurs français

English descriptors

Abstract

The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic mice. The results showed that 50% fraction could increase insulin sensitivity and reduce insulin resistance, as well as decrease the levels of fasting blood glucose, glycated hemoglobin, and glycosylated serum proteins in diabetic mice. Compared with the model control group, the 50% fraction-treated group showed significant decreases of malondialdehyde (MDA) and increases of superoxide dismutase (SOD) in serum and liver homogenate. Moreover, 50% fraction could significantly decrease total cholesterol (TC), alleviate abnormal lipid metabolism, and enhance antioxidant capacity in the serum. For inflammatory factors, feeding of 50% fraction could also reduce the levels of interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), monocyte chemotactic protein 1 (MCP-1), and cyclooxygenase-2 (COX-2) in liver homogenate. Taken together, our results suggest that crude extract and 50% fraction of poplar buds, particularly the latter, can decrease blood glucose levels and insulin resistance, and 50% fraction can significantly relieve dyslipidemia, oxidative stress, and inflammation caused by type-2 diabetes.

DOI: 10.1155/2018/7245956
PubMed: 30320140
PubMed Central: PMC6167568


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Le document en format XML

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<term>Animals (MeSH)</term>
<term>Cyclooxygenase 2 (metabolism)</term>
<term>Cytokines (metabolism)</term>
<term>Diabetes Complications (drug therapy)</term>
<term>Diabetes Mellitus, Experimental (MeSH)</term>
<term>Diabetes Mellitus, Type 2 (drug therapy)</term>
<term>Disease Models, Animal (MeSH)</term>
<term>Dyslipidemias (drug therapy)</term>
<term>Humans (MeSH)</term>
<term>Hyperglycemia (drug therapy)</term>
<term>Inflammation (drug therapy)</term>
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<term>Liver (metabolism)</term>
<term>Liver (pathology)</term>
<term>Male (MeSH)</term>
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<term>Oxidative Stress (drug effects)</term>
<term>Plant Extracts (therapeutic use)</term>
<term>Populus (immunology)</term>
<term>Propolis (immunology)</term>
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<term>Animaux (MeSH)</term>
<term>Complications du diabète (traitement médicamenteux)</term>
<term>Cyclooxygenase 2 (métabolisme)</term>
<term>Cytokines (métabolisme)</term>
<term>Diabète de type 2 (traitement médicamenteux)</term>
<term>Diabète expérimental (MeSH)</term>
<term>Dyslipidémies (traitement médicamenteux)</term>
<term>Extraits de plantes (usage thérapeutique)</term>
<term>Foie (anatomopathologie)</term>
<term>Foie (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Hyperglycémie (traitement médicamenteux)</term>
<term>Inflammation (traitement médicamenteux)</term>
<term>Insulinorésistance (MeSH)</term>
<term>Lignées consanguines de souris (MeSH)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Populus (immunologie)</term>
<term>Propolis (immunologie)</term>
<term>Souris (MeSH)</term>
<term>Stress oxydatif (effets des médicaments et des substances chimiques)</term>
</keywords>
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<term>Propolis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Cyclooxygenase 2</term>
<term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Foie</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Diabetes Complications</term>
<term>Diabetes Mellitus, Type 2</term>
<term>Dyslipidemias</term>
<term>Hyperglycemia</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr">
<term>Stress oxydatif</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Populus</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Cyclooxygenase 2</term>
<term>Cytokines</term>
<term>Foie</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Liver</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr">
<term>Complications du diabète</term>
<term>Diabète de type 2</term>
<term>Dyslipidémies</term>
<term>Hyperglycémie</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr">
<term>Extraits de plantes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Diabetes Mellitus, Experimental</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Insulin Resistance</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred Strains</term>
</keywords>
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<term>Animaux</term>
<term>Diabète expérimental</term>
<term>Humains</term>
<term>Insulinorésistance</term>
<term>Lignées consanguines de souris</term>
<term>Modèles animaux de maladie humaine</term>
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<div type="abstract" xml:lang="en">The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic mice. The results showed that 50% fraction could increase insulin sensitivity and reduce insulin resistance, as well as decrease the levels of fasting blood glucose, glycated hemoglobin, and glycosylated serum proteins in diabetic mice. Compared with the model control group, the 50% fraction-treated group showed significant decreases of malondialdehyde (MDA) and increases of superoxide dismutase (SOD) in serum and liver homogenate. Moreover, 50% fraction could significantly decrease total cholesterol (TC), alleviate abnormal lipid metabolism, and enhance antioxidant capacity in the serum. For inflammatory factors, feeding of 50% fraction could also reduce the levels of interleukin 6 (IL-6), tumor necrosis factor
<i>α</i>
(TNF-
<i>α</i>
), monocyte chemotactic protein 1 (MCP-1), and cyclooxygenase-2 (COX-2) in liver homogenate. Taken together, our results suggest that crude extract and 50% fraction of poplar buds, particularly the latter, can decrease blood glucose levels and insulin resistance, and 50% fraction can significantly relieve dyslipidemia, oxidative stress, and inflammation caused by type-2 diabetes.</div>
</front>
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<Day>27</Day>
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<Title>Journal of immunology research</Title>
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<ArticleTitle>Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes.</ArticleTitle>
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<AbstractText>The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic mice. The results showed that 50% fraction could increase insulin sensitivity and reduce insulin resistance, as well as decrease the levels of fasting blood glucose, glycated hemoglobin, and glycosylated serum proteins in diabetic mice. Compared with the model control group, the 50% fraction-treated group showed significant decreases of malondialdehyde (MDA) and increases of superoxide dismutase (SOD) in serum and liver homogenate. Moreover, 50% fraction could significantly decrease total cholesterol (TC), alleviate abnormal lipid metabolism, and enhance antioxidant capacity in the serum. For inflammatory factors, feeding of 50% fraction could also reduce the levels of interleukin 6 (IL-6), tumor necrosis factor
<i>α</i>
(TNF-
<i>α</i>
), monocyte chemotactic protein 1 (MCP-1), and cyclooxygenase-2 (COX-2) in liver homogenate. Taken together, our results suggest that crude extract and 50% fraction of poplar buds, particularly the latter, can decrease blood glucose levels and insulin resistance, and 50% fraction can significantly relieve dyslipidemia, oxidative stress, and inflammation caused by type-2 diabetes.</AbstractText>
</Abstract>
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<LastName>Peng</LastName>
<ForeName>Shiqin</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
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<LastName>Wei</LastName>
<ForeName>Ping</ForeName>
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<AffiliationInfo>
<Affiliation>College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
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<LastName>Lu</LastName>
<ForeName>Qun</ForeName>
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<Identifier Source="ORCID">0000-0002-6211-6565</Identifier>
<AffiliationInfo>
<Affiliation>College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Wuhan Engineering Research Center of Bee Products on Quality and Safety Control, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Liu</LastName>
<ForeName>Rui</ForeName>
<Initials>R</Initials>
<Identifier Source="ORCID">0000-0001-5820-0177</Identifier>
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<Affiliation>College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Wuhan Engineering Research Center of Bee Products on Quality and Safety Control, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan 430070, China.</Affiliation>
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<LastName>Ding</LastName>
<ForeName>Yue</ForeName>
<Initials>Y</Initials>
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</AffiliationInfo>
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<LastName>Zhang</LastName>
<ForeName>Jiuliang</ForeName>
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<Affiliation>College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Wuhan Engineering Research Center of Bee Products on Quality and Safety Control, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan 430070, China.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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</PublicationTypeList>
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<Year>2018</Year>
<Month>09</Month>
<Day>18</Day>
</ArticleDate>
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<Country>Egypt</Country>
<MedlineTA>J Immunol Res</MedlineTA>
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<ISSNLinking>2314-7156</ISSNLinking>
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<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
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<Chemical>
<RegistryNumber>9009-62-5</RegistryNumber>
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</Chemical>
<Chemical>
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<MeshHeadingList>
<MeshHeading>
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</MeshHeading>
<MeshHeading>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading>
<DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
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</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007333" MajorTopicYN="N">Insulin Resistance</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008815" MajorTopicYN="N">Mice, Inbred Strains</DescriptorName>
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<DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
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<DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
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<MeshHeading>
<DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<MeshHeading>
<DescriptorName UI="D011429" MajorTopicYN="N">Propolis</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<Month>07</Month>
<Day>15</Day>
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<Month>07</Month>
<Day>26</Day>
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